Airway inflammation despite loss of bronchial hyper-responsiveness after multiple ozone exposures
نویسندگان
چکیده
منابع مشابه
Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness
BACKGROUND Swine farmers repeatedly exposed to the barn air suffer from respiratory diseases. However the mechanisms of lung dysfunction following repeated exposures to the barn air are still largely unknown. Therefore, we tested a hypothesis in a rat model that multiple interrupted exposures to the barn air will cause chronic lung inflammation and decline in lung function. METHODS Rats were ...
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1. Bronchial responsiveness to inhaled methacholine was studied in ten heart-lung transplant (HLT) recipients a mean 10.6 months (range 1.5-28 months) post-HLT and in ten normal subjects. 2. The mean provocation dose of methacholine producing a 20% fall in FEV1 (PD20 FEV1) was significantly lower in the HLT recipients (1.70 +/- 3.96 mg vs 11.55 +/- 3.79 mg; P less than 0.001), as was the mean p...
متن کاملBronchial responsiveness and airway inflammation in trained subjects
siveness (BHR) and physical activity. Several hypotheses are invoked to explain this association, including a suggestion that physical activity reduces bronchial inflammation by altering airway physiology. Their major hypothesis is that obesity reduces physical activity and that it is this reduction in physical activity which causes, in some mysterious way, the increase in BHR observed. Their p...
متن کاملBronchial responsiveness and airway inflammation in trained subjects
siveness (BHR) and physical activity. Several hypotheses are invoked to explain this association, including a suggestion that physical activity reduces bronchial inflammation by altering airway physiology. Their major hypothesis is that obesity reduces physical activity and that it is this reduction in physical activity which causes, in some mysterious way, the increase in BHR observed. Their p...
متن کاملBronchial responsiveness and airway inflammation in trained subjects.
siveness (BHR) and physical activity. Several hypotheses are invoked to explain this association, including a suggestion that physical activity reduces bronchial inflammation by altering airway physiology. Their major hypothesis is that obesity reduces physical activity and that it is this reduction in physical activity which causes, in some mysterious way, the increase in BHR observed. Their p...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 1997
ISSN: 0954-6111
DOI: 10.1016/s0954-6111(97)90136-0